big bang theory
Despite a highly successful career as an engineer and astronaut, Howard Wolowitz (Simon Helberg) gets mocked constantly by his friends in The Big Bang Theory. He considers himself a ladies man, but that female attention comes mainly from his mother.
In The Big Bang Theory, Sheldon Cooper (Jim Parsons) has a genius IQ and photographic memory, though he spends most of those brain cycles on comic books, sci-fi, and sci-fi comic books. He himself enjoys costumes, even dressing up as Raggedy C3P-O one Halloween.