In Star Trek, Spock (Leonard Nimoy, Zachary Quinto) serves as first officer of the U.S.S. Enterprise. Having a mixed human and Vulcan heritage, he had a troubled childhood but has learned to use his unique perspective to his advantage.
In Star Trek: The Next Generation, Dr. Beverly Crusher (Gates McFadden) is the chief medical officer of the U.S.S. Enterprise. She is also notable for being the mother of Wesley Crusher.
In Star Trek: Voyager, Seven of Nine (Jeri Ryan) serves on the USS Voyager. Born Annika Hansen, she was assimilated by the Borg at age 6, but the Doctor is able to remove most of her cybernetic implants and restore her humanity.