In Pixels, Lady Lisa (Ashley Benson) may be the main character of the video game Dojo Quest, but that doesn’t stop the weird but brilliant Ludlow Lamonsoff from falling in love with the beautiful pixellated warrioress.
In Archer, Dr. Krieger’s girlfriend (voiced by Judy Greer) is a virtual hologram who looks like an anime character. Despite being a computer generated image, she’s self-aware and is so convincingly real that the state of New York has even allowed Dr. Krieger to marry her.
In Season 2 of Gravity Falls, Giffany is a sentient dating simulator program in a game called “Romance Academy 7”. She makes her appearance in the episode “Soos and the Real Girl”. Soos bought the game in order to get practice to date real girls.