In Animaniacs, Hello Nurse is a buxom studio nurse who Yakko and Wakko constantly fawn over. Naturally they do their best to get injured so they can get her attention, exclaiming “hellooooooo, nurse” whenever she enters the room. It’s later revealed that not only is she beautiful but that she has a genius IQ of 192.
Blink-182’s 1999 release Enema of the State was a runaway success. The album cover features Janine Lindemulder in a scantily clad nurse’s uniform, which probably had something to do with that.