In Maniac, Dr. James Mantleray (Justin Theroux) is a scientist working on the Neberdine Pharmaceutical Biotech (NPB) experiment. After the lead scientist of the project dies, Dr. Mantleray — who created the ULP drugs used in the experiment — his brought back to head the project. He’s intelligent and well-meaning, but not without his own flaws, least of which his poor-fitting toupee.

In Maniac, Annie Landsberg (Emma Stone) has a shared B-pill induced dream with Owen Milgram that they are married couple Linda and Bruce Marino. Lin works hospice and gets pulled into a scheme to recover a ring-tailed lemur that belongs to one of her patients after it’s been stolen by furriers planning to make it into a hat.

In Maniac, Bruce Marino (Jonah Hill) is an identity that Owen Milgram takes on in an A-pill inducted dream. With “wife” Linda, he schemes to rescue a ring-tailed lemur from a thuggish fur shop owner while New York Fish and Wildlife are hot on their tails.

In Maniac, Annie Landsberg (Emma Stone) is a deeply unhappy and anti-social woman who dwells unhealthily on her relationships. In particular she is troubled by the traumatic circumstances of her sister’s death, which she deals with by abusing experimental drugs, going as far as to sign up for Neberdine ‘s pharmaceutical trials to gain access to them.