Leon S Kennedy is the main protagonist of the zombie action survival horror game Resident Evil 4. Leon is a secret agent for the U.S. federal government assigned to rescue the president’s daughter from a sinister cult in Spain. Along the way, he uncovers an ancient conspiracy possibly linked to his greatest foe, Wesker.

In this adventure game, Fran Bow is a young girl struggling with mental disorder and an unfair destiny at an oppressive mental asylum. All this after she witnesses the gruesome murder of her parents and is left alone with her cat and only friend, Mr. Midnight.

In Resident Evil, Jill Valentine is an explosives expert who’s worked with the U.S. Army and the Raccoon Police Department. In RE3: Nemesis, she’s forced to partner with an ex-member of the Umbrella Corporations paramilitary force in order to escape Raccoon City before a nuke strikes it.

In Metal Gear Solid V: The Phantom Pain, Quiet (voiced by Stefanie Joosten) is an AI sniper with supernatural abilities that Snake can call upon to assist him on missions. As her name suggests, she doesn’t talk much, but she can get the job done.

In the Metal Gear Solid series, Solid Snake is special ops agent who infiltrates enemy installations and disrupts their operations. When he’s vastly outnumbered, he’ll do whatever it takes to remain stealthy, and isn’t above camping out in a cardboard box.

In the Portal games, Chell is essentially a lab rat for Aperture Science, performing tests under the supervision of the AI bot GLaDOS. It’s not long before Chell sees her chance to escape the testing facility using her portal gun.