In the Portal games, Chell is essentially a lab rat for Aperture Science, performing tests under the supervision of the AI bot GLaDOS. It’s not long before Chell sees her chance to escape the testing facility using her portal gun.

In Metal Gear Solid V: The Phantom Pain, Quiet (voiced by Stefanie Joosten) is an AI sniper with supernatural abilities that Snake can call upon to assist him on missions. As her name suggests, she doesn’t talk much, but she can get the job done.

Leon S Kennedy is the main protagonist of the zombie action survival horror game Resident Evil 4. Leon is a secret agent for the U.S. federal government assigned to rescue the president’s daughter from a sinister cult in Spain. Along the way, he uncovers an ancient conspiracy possibly linked to his greatest foe, Wesker.

Lara Croft is just your average run-of-the-mill English archaeologist. Dodging boulders, navigating through ancient ruins, and fighting giant stone statues is just your typical day for this video game icon. She’s been somersaulting through hazardous tombs for over a decade and she’s only getting better.

In this adventure game, Fran Bow is a young girl struggling with mental disorder and an unfair destiny at an oppressive mental asylum. All this after she witnesses the gruesome murder of her parents and is left alone with her cat and only friend, Mr. Midnight.

In the Metal Gear Solid series, Solid Snake is special ops agent who infiltrates enemy installations and disrupts their operations. When he’s vastly outnumbered, he’ll do whatever it takes to remain stealthy, and isn’t above camping out in a cardboard box.